Vasopressin/oxytocin-related peptides influence long-term memory of a passive avoidance task in the cuttlefish, Sepia officinalis

Publication Type:Journal Article
Year of Publication:2010
Authors:I. Bardou, Leprince, J., Chichery, R., Vaudry, H., Agin, V.
Journal:Neurobiology of Learning and Memory
Volume:93
Pagination:240-247
Date Published:Feb
Type of Article:Article
ISBN Number:1074-7427
Accession Number:ISI:000275312200013
Keywords:8-ARM RADIAL, Cephalopods, Cephalotocin, CHOLINERGIC MECHANISMS, Consolidation processes, INVERTEBRATE OXYTOCIN/VASOPRESSIN SUPERFAMILY, Long-term, MAZE, memory, NERVOUS-SYSTEM, neuropeptides, Octopressin, OCTOPUS OCTOPUS-VULGARIS, optic lobe, Oxytocin/vasopressin, Passive avoidance learning, SCOPOLAMINE-INDUCED IMPAIRMENTS, spatial memory, superfamily, UROTENSIN-II, VERTICAL LOBE COMPLEX
Abstract:

The vasopressin (VP)/oxytocin (OT)-related peptides constitute a large superfamily found in a wide range of both vertebrate and invertebrate species. While intensive literature reports that these neuropeptides influence behavior, especially learning and memory, in numerous species from diverse vertebrate groups, their roles in behavioral regulation have never been studied in invertebrates. Here, we investigated the role of two VP/OT superfamily peptides, octopressin (OP) and cephalotocin (CT), on long-term memory (LTM) formation of a passive avoidance task in a cephalopod mollusc, the cuttlefish, Sepia officinalis. Sub-adult cuttlefish were intravenously injected, in a dose range of 3-60 mu g/kg, 1 h after the training phase (consolidation design); retention performance was tested 24 h post-training. We found that administration of OP at low dose (3 mu g/kg) enhanced LTM, whereas a dose of 60 mu g/kg attenuated it. No effect of OP on LTM was observed for the 15 mu g/kg dose. Conversely, an enhancement of retention performance was observed at all doses of CT tested. This study is the first to demonstrate the behavioral effects of VP/OT superfamily peptides in an invertebrate species. The valuable role of VP/OT-like peptides on memory processes offers new evolutionary perspectives on peptidergic transmission and neuromodulation. (C) 2009 Elsevier Inc. All rights reserved.

Short Title:Neurobiol. Learn. Mem.Neurobiol. Learn. Mem.
Alternate Journal:Neurobiol. Learn. Mem.
Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith